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Pancreatitis severity calculator

Modified Glasgow (Imrie) score, PANCREAS mnemonic, and BISAP.

Acute pancreatitis: is this attack likely to be severe?

Modified Glasgow (Imrie) score, within 48 hours

BISAP score, within 24 hours

Why we score pancreatitis

Four out of five attacks of acute pancreatitis are mild and settle in a few days. The rest can cause organ failure, necrosis and death. Scores taken in the first 24 to 48 hours pick out the patients who need closer monitoring before they become obviously unwell.

Severity is defined by organ failure (revised Atlanta 2012)

GradeDefinition
MildNo organ failure and no local or systemic complications
Moderately severeOrgan failure that resolves within 48 hours, or local complications (collections, necrosis), or worsening of a pre-existing disease
SevereOrgan failure that persists beyond 48 hours

So a score predicts severity; it does not define it. The final grade is decided by how the patient’s organs behave.

A worked example

A 67-year-old woman with gallstone pancreatitis. At 48 hours: age over 55, white cells 17.4, urea 18 mmol/L, glucose 12 mmol/L. Glasgow 4: predicted severe. On admission she was confused with a pulse of 112 and a temperature of 38.4 °C: BISAP has age, SIRS and impaired mental status, BISAP 3. She is discussed with critical care.

Things students get wrong

The amylase level does not predict severity and is not in any of these scores. A CRP above 150 mg/L at 48 hours is another useful marker of severity. CT is not needed for diagnosis when the story and enzymes fit; it is used after 72 hours to look for necrosis in a patient who is not improving.

References

  1. Blamey SL, Imrie CW, et al. Prognostic factors in acute pancreatitis. Gut 1984;25:1340–6.
  2. Wu BU, et al. The early prediction of mortality in acute pancreatitis: a large population-based study (BISAP). Gut 2008;57:1698–703.
  3. Banks PA, et al. Classification of acute pancreatitis 2012: revision of the Atlanta classification. Gut 2013;62:102–11.
  4. Leppäniemi A, et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg 2019;14:27.

Educational use

This calculator is a teaching aid. It does not replace clinical judgement, senior advice or your local guidelines.

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